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Version: 11-September-2012 Alternate Names: HMDH_HUMAN Uniprot Id HMGCR Uniprot Gene Name P04035 Uniprot Accession Gene … Gene; Hmgcr; Hmgcr. Addgene Alerts Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description HMG Coenzyme A reductase Also known as Dmel_CG10367, BcDNA:LD15354, CG10367, Clb, DmHMG-CoAr, Dmel\CG10367, HMGCR, HMGCR HMGCR gene expression in animals with extreme lipid metabolism and its relationship with phenotypic measures. Figure 2b presents the comparison of HMGCR muscle and liver expression levels in two groups of Duroc pigs corresponding to the most extreme animals for 13 traits related to growth, HMGCR gene product. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. 2021-01-22 A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study - Volume 104 Issue 5 Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio 2011-01-31 2017-11-20 Gene name.

Hmgcr gene

Imirestat. Aldose reductase - Wikipedia. HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. The study investigated cancer risk for a single-nucleotide polymorphisms (SNP rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment. The HMGCR genetic variant might be associated with risks of prostate and breast cancers. HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase (human) HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene.

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Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids. HMGCR protein and Hmgcr mRNA levels of DMSO-treated cells were defined as 1.

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Catalog # 1320001 20 nmol; Price: See in cart Your Price: Online offer: Check your price › Add To Cart Add to Array HMGCR Gene Expression in HepG2 Cell Lines (Sarang Burung Wale t (EBN) Berdos Tinggi Meningkatkan LDL-R melalui Perencatan Gen HMGCR dalam Sel HepG2) MOHD NOOR AKMAL, ABDUL RAZAK INTAN-SHAMEHA, ROZAIHAN MANSOR, AINI IDERIS, ABDUL RAHMAN OMAR, JALILA ABU, MOHD FAIZ IDRIS & MOKRISH AJAT* 2012-03-20 HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.

Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Summary of HMGCR This gene encodes an enzyme that catalyzes the rate limiting step in cholesterol biosynthesis (R). 0 users want this gene increased, 0 users want it decreased The Function of HMGCR Luskey (1987) determined that the human HMGCR gene has several transcriptional start sites that generate relatively short 5-prime UTRs of 73 to 105 nucleotides. As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information.
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Provided by metabolicatlas.org: Pathway / Subsystem Compartments # proteins # metabolites # reactions for this protein; Transport reactions The HMGCR gene encodes HMG-CoA reductase, a protein best known as being the target for drugs designed to reduce cholesterol levels and thereby reduce the risk for heart disease. SNPs in HMGCR can influence how well such drugs work; they include: rs17244841; rs17238540 HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2: Protein Coding: 51: GC01P056645: 6.85: 3: INSIG1: Insulin Induced Gene 1: Protein Coding: 41: GC07P155297: 6.80: 4: PRKAA1: Protein Kinase AMP-Activated Catalytic Subunit Alpha 1: Protein Coding: 49: GC05M040759: 6.78: 5: APOE: Apolipoprotein E 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), 3-hydroxy-3-methylglutaryl coenzyme A reductase; This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.

HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary.
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31 Jan 2011 3-Hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase gene (Hmgcr) is a susceptibility gene for essential hypertension. Sequencing of 21 Aug 2019 Regulatory mechanism of HMGCR.

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As in the hamster Hmgcr gene, this upstream region provides sites for statin-dependent induction and sterol-dependent suppression. Gene: Hmgcr - ENSMUSG00000021670 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids.